Microinfarct disruption of white matter structure: a longitudinal diffusion tensor analysis.

ABSTRACT:

Objective

To evaluate the local effect of small asymptomatic infarctions detected by diffusion-weighted imaging (DWI) on white matter microstructure using longitudinal structural and diffusion tensor imaging (DTI).

Methods

Nine acute to subacute DWI lesions were identified in 6 subjects with probable cerebral amyloid angiopathy who had undergone high-resolution MRI both before and after DWI lesion detection. Regions of interest (ROIs) corresponding to the site of the DWI lesion (lesion ROI) and corresponding site in the nonlesioned contralateral hemisphere (control ROI) were coregistered to the pre- and postlesional scans. DTI tractography was additionally performed to reconstruct the white matter tracts containing the ROIs. DTI parameters (fractional anisotropy [FA], mean d

SUBMITTER: Auriel E 

PROVIDER: S-EPMC4117171 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature