Eradication of multidrug-resistant A. baumannii in burn wounds by antiseptic pulsed electric field.

ABSTRACT: Emerging bacterial resistance to multiple drugs is an increasing problem in burn wound management. New non-pharmacologic interventions are needed for burn wound disinfection. Here we report on a novel physical method for disinfection: antiseptic pulsed electric field (PEF) applied externally to the infected burns. In a mice model, we show that PEF can reduce the load of multidrug resistant Acinetobacter baumannii present in a full thickness burn wound by more than four orders of magnitude, as detected by bioluminescence imaging. Furthermore, using a finite element numerical model, we demonstrate that PEF provides non-thermal, homogeneous, full thickness treatment for the burn wound, thus, overcoming the limitation of treatment depth for many topical antimicrobials. These modeling to

SUBMITTER: Golberg A 

PROVIDER: S-EPMC4117356 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature