Functional connectivity in the basal ganglia network differentiates PD patients from controls.

ABSTRACT:

Objective

To examine functional connectivity within the basal ganglia network (BGN) in a group of cognitively normal patients with early Parkinson disease (PD) on and off medication compared to age- and sex-matched healthy controls (HC), and to validate the findings in a separate cohort of participants with PD.

Methods

Participants were scanned with resting-state fMRI (RS-fMRI) at 3T field strength. Resting-state networks were isolated using independent component analysis. A BGN template was derived from 80 elderly HC participants. BGN maps were compared between 19 patients with PD on and off medication in the discovery group and 19 age- and sex-matched controls to identify a threshold for optimal group separation. The threshold was applied to 13 patients with PD (including

SUBMITTER: Szewczyk-Krolikowski K 

PROVIDER: S-EPMC4117363 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature