Regioselective hydroacylation of 1,3-dienes by cobalt catalysis.

ABSTRACT: We describe a cobalt-catalyzed hydroacylation of 1,3-dienes with non-chelating aldehydes. Aromatic aldehydes provide 1,4-addition products as the major isomer, while aliphatic aldehydes favor 1,2-hydroacylation products. The kinetic profile supports an oxidative cyclization mechanism involving a cobaltacycle intermediate that undergoes transformation with high regio- and stereoselectivity.

SUBMITTER: Chen QA 

PROVIDER: S-EPMC4117386 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature