Comparative effectiveness of early versus conventional timing of dialysis initiation in advanced CKD.

ABSTRACT:

Background

Previous observational studies examining outcomes associated with the timing of dialysis therapy initiation in the United States have often been limited by lead time and survivor bias.

Study design

Retrospective cohort study comparing the effectiveness of early versus later (conventional) dialysis therapy initiation in advanced chronic kidney disease (CKD). The analysis used inverse probability weighting to account for an individual's contribution to different exposure groups over time in a pooled logistic regression model. Patients contributed risk to both exposure categories (early and later initiation) until there was a clear treatment strategy (ie, dialysis therapy was initiated early or estimated glomerular filtration rate [eGFR] decreased to <10mL/min/1.73m(

SUBMITTER: Crews DC 

PROVIDER: S-EPMC4117406 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature