The association between sleep characteristics and prothrombotic markers in a population-based sample: Chicago Area Sleep Study.

ABSTRACT:

Background and aim

Short sleep duration and poor quality sleep are associated with coronary heart disease (CHD) mortality; however, the underlying pathophysiologic process remains unclear. Sleep apnea may confound the association because of its relationship with formation of thrombi, the vascular occlusive process in CHD. We tested whether sleep duration and quality were associated with prothrombotic biomarkers in adults with a low probability of apnea.

Methods

We included adults aged 35-64 years recruited from the community and who had an apnea hypopnea index <15 after one night of screening (n=506). Sleep duration and maintenance were determined from 7 days of wrist actigraphy; daytime sleepiness was estimated using the Epworth Sleepiness Scale. Factor VIII (FVIII), von Wi

SUBMITTER: Tosur Z 

PROVIDER: S-EPMC4117713 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature