Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum.

ABSTRACT:

Objective

The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. We examined in detail the distribution of the full range of cell lineages within the human stomach.

Design

We determined the distribution of gastric gland cell lineages with specific immunocytochemical markers in entire stomach specimens from three non-obese organ donors.

Results

The anatomical body and antrum of the human stomach were defined by the presence of ghrelin and gastrin cells, respectively. Concentrations of somatostatin cells were observed in the proximal stomach. Parietal cells were seen in all glands of the body of the stomach as

SUBMITTER: Choi E 

PROVIDER: S-EPMC4117823 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature