FGF23 protein expression in coronary arteries is associated with impaired kidney function.

ABSTRACT:

Background

Fibroblast growth factor 23 (FGF23) levels are elevated in chronic kidney disease (CKD) and elevated values have been associated with both heart disease and mortality. Recent studies show that FGF23, a protein synthesized by osteocytes, is also present in calcified atherosclerotic plaques and may be induced by heart disease. Whether vascular expression of FGF23 is associated with progressive CKD, however, remains unknown. Therefore, the relationship between kidney function, vascular calcification and FGF23 expression was evaluated in patients with heart disease.

Methods

Immunohistochemistry for FGF23 was performed in coronary arteries of all patients undergoing heart transplantation at UCLA between February 2008 and 2010. Immunohistochemical staining for Klotho, D

SUBMITTER: van Venrooij NA 

PROVIDER: S-EPMC4118139 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature