β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice.

ABSTRACT:

Rationale

Abdominal aortic aneurysms (AAAs) are a chronic inflammatory vascular disease for which pharmacological treatments are not available. A mouse model of AAA formation involves chronic infusion of angiotensin II (AngII), and previous studies indicated a primary role for the AngII type 1a receptor in AAA formation. β-arrestin (βarr)-2 is a multifunctional scaffolding protein that binds G-protein-coupled receptors such as AngII type 1a and regulates numerous signaling pathways and pathophysiological processes. However, a role for βarr2 in AngII-induced AAA formation is currently unknown.

Objective

To determine whether βarr2 played a role in AngII-induced AAA formation in mice.

Methods and results

Treatment of βarr2(+/+) and βarr2(-/-) mice on the hyperlipidemic a

SUBMITTER: Trivedi DB 

PROVIDER: S-EPMC4118213 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature