Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine.

ABSTRACT: Hypoxemic respiratory failure of the neonatal organism involves increased acid sphingomyelinase (aSMase) activity and production of ceramide, a second messenger of a pro-inflammatory pathway that promotes increased vascular permeability, surfactant alterations and alveolar epithelial apoptosis. We comparatively assessed the benefits of topical aSMase inhibition by either imipramine (Imi) or phosphatidylinositol-3,5-bisphosphate (PIP2) when administered into the airways together with surfactant (S) for fortification. In this translational study, a triple-hit acute lung injury model was used that entails repeated airway lavage, injurious ventilation and tracheal lipopolysaccharide instillation in newborn piglets subject to mechanical ventilation for 72 hrs. After randomization, we administer

SUBMITTER: Preuss S 

PROVIDER: S-EPMC4118249 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature