Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion.

ABSTRACT:

Background

Longitudinal axons grow parallel to the embryonic midline to connect distant regions of the central nervous system. Previous studies suggested that repulsive midline signals guide pioneer longitudinal axons by blocking their entry into the floor plate; however, the role of midline attractants, and whether attractant signals may cooperate with repulsive signals, remains unclear. In this study we investigated the navigation of a set of pioneer longitudinal axons, the medial longitudinal fasciculus, in mouse embryos mutant for the Netrin/Deleted in Colorectal Cancer (DCC) attractants, and for Slit repellents, as well as the responses of explanted longitudinal axons in vitro.

Results

In mutants for Netrin1 chemoattractant or DCC receptor signaling, longitudinal axons

SUBMITTER: Kim M 

PROVIDER: S-EPMC4118263 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature