Pharmacogenetics of heart failure.

ABSTRACT:

Purpose of review

Novel medical approaches and personalized medicine seek to use genetic information to 'individualize' and improve diagnosis, prevention, and therapy. The personalized management of cardiovascular disease involves a large spectrum of potential applications, from diagnostics of monogenic disorders, to prevention and management strategies based on modifier genes, to pharmacogenetics, in which individual genetic information is used to optimize the pharmacological treatments.

Recent findings

Evidence suggests that the common polymorphic variants of modifier genes could influence drug response in cardiovascular disease in a variety of areas, including heart failure, arrhythmias, dyslipidemia, and hypertension. In heart failure, common genetic variants of β-adrene

SUBMITTER: Mestroni L 

PROVIDER: S-EPMC4118293 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature