Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence.

ABSTRACT: Cellular senescence, which is known to halt proliferation of aged and stressed cells, plays a key role against cancer development and is also closely associated with organismal aging. While increased insulin-like growth factor (IGF) signaling induces cell proliferation, survival and cancer progression, disrupted IGF signaling is known to enhance longevity concomitantly with delay in aging processes. The molecular mechanisms involved in the regulation of aging by IGF signaling and whether IGF regulates cellular senescence are still poorly understood. In this study, we demonstrate that IGF-1 exerts a dual function in promoting cell proliferation as well as cellular senescence. While acute IGF-1 exposure promotes cell proliferation and is opposed by p53, prolonged IGF-1 treatment induces prem

SUBMITTER: Tran D 

PROVIDER: S-EPMC4118446 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature