Routine clinical evaluation of cerebrovascular reserve capacity using carbogen in patients with intracranial stenosis.

ABSTRACT:

Background and purpose

A promising method for identifying hemodynamic impairment that may serve as a biomarker for stroke risk in patients with intracranial stenosis is cerebrovascular reactivity (CVR) mapping using noninvasive MRI. Here, abilities to measure CVR safely in the clinic using hypercarbic hyperoxic (carbogen) gas challenges, which increase oxygen delivery to tissue, are investigated.

Methods

In sequence with structural and angiographic imaging, blood oxygenation level-dependent carbogen-induced CVR scans were performed in patients with symptomatic intracranial stenosis (n=92) and control (n=10) volunteers, with a subgroup of patients (n=57) undergoing cerebral blood flow-weighted pseudocontinuous arterial spin labeling CVR. Subjects were stratified for 4 substud

SUBMITTER: Donahue MJ 

PROVIDER: S-EPMC4118584 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature