Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury.

ABSTRACT: Fractionated partial or whole-brain irradiation is the primary treatment for metastatic brain tumors. Despite reducing tumor burden and increasing lifespan, progressive, irreversible cognitive impairment occurs in >50% of the patients who survive >6 months after fractionated whole-brain irradiation. The exact mechanism(s) responsible for this radiation-induced brain injury are unknown; however, preclinical studies suggest that radiation modulates the extracellular receptor kinase signaling pathway, which is associated with cognitive impairment in many neurological diseases. In the study reported here, we demonstrated that the extracellular receptor kinase transcriptionally-regulated early response gene, Homer1a, was up-regulated transiently in the hippocampus and down-regulated in the cort

SUBMITTER: Moore ED 

PROVIDER: S-EPMC4118588 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature