Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo.

ABSTRACT: Once programmed to acquire a specific identity and function, cells rarely change in vivo. Neurons of the mammalian central nervous system (CNS) in particular are a classic example of a stable, terminally differentiated cell type. With the exception of the adult neurogenic niches, where a limited set of neuronal subtypes continue to be generated throughout life, CNS neurons are born only during embryonic and early postnatal development. Once generated, neurons become permanently post-mitotic and do not change their identity for the lifespan of the organism. Here, we have investigated whether excitatory neurons of the neocortex can be instructed to directly reprogram their identity post-mitotically from one subtype into another, in vivo. We show that embryonic and early postnatal callosal pr

SUBMITTER: Rouaux C 

PROVIDER: S-EPMC4118591 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature