Inteleukin-23 promotes interferon-α responsiveness in hepatitis C virus/HIV-coinfected patients.

ABSTRACT: Patients coinfected with HIV and hepatitis C virus (HCV) have poor to modest rates of response with interferon-based therapies, which remain a backbone of the treatment in HIV/HCV-coinfected patients. The mechanisms responsible for poor responsiveness to interferon are not well described. In this study a targeted proteomic analysis of plasma from 42 patients infected with both HIV and HCV and undergoing therapy for HCV with peginterferon and ribavirin was performed. Higher baseline plasma levels of interleukin (IL)-23 were associated with sustained virologic response. Further investigation of how IL-23 facilitates interferon (IFN) responsiveness, as evidenced by a >2-fold increase in most interferon-stimulated genes (ISGs), revealed that IL-23 indirectly enhances IFN signaling in periphera

SUBMITTER: Odigie M 

PROVIDER: S-EPMC4118700 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature