Genetic predictors of cervical dysplasia in African American HIV-infected women: ACTG DACS 268.

ABSTRACT:

Objective

To examine genome-wide associations in HIV-infected women with a history of cervical dysplasia compared with HIV-infected women with no history of abnormal Papanicolaou (Pap) tests.

Design

Case-control study using data from women analyzed for the HIV Controllers Study and enrolled in HIV treatment-naïve studies in the AIDS Clinical Trials Group (ACTG).

Methods

Genotyping utilized Illumina HumanHap 650 Y or 1MDuo platforms. After quality control and principal component analysis, ~610,000 significant single nucleotide polymorphisms (SNPs) were tested for association. Threshold for significance was P < 5 × 10(-8) for genome-wide associations.

Results

No significant genomic association was observed between women with low-grade dysplasia and controls. The

SUBMITTER: Cespedes MS 

PROVIDER: S-EPMC4118741 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature