The role of clusterin in amyloid-β-associated neurodegeneration.

ABSTRACT:

Importance

Converging evidence indicates that clusterin, a chaperone glycoprotein, influences Alzheimer disease neurodegeneration. However, the precise role of clusterin in Alzheimer disease pathogenesis is still not well understood.

Objective

To elucidate the relationship between clusterin, amyloid-β (Aβ), phosphorylated tau (p-tau), and the rate of brain atrophy over time among nondemented older individuals.

Design, setting, and participants

This longitudinal cohort included cognitively normal older participants and individuals with mild cognitive impairment assessed with baseline lumbar puncture and longitudinal structural magnetic resonance imaging. We examined 241 nondemented older individuals from research centers across the United States and Canada (91 particip

SUBMITTER: Desikan RS 

PROVIDER: S-EPMC4118752 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature