Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases.

ABSTRACT: Lymph-node metastasis (LNM) predict high recurrence rates in breast cancer patients. Systemic treatment aims to eliminate (micro)metastatic cells. However decisions regarding systemic treatment depend largely on clinical and molecular characteristics of primary tumours. It remains, however, unclear to what extent metastases resemble the cognate primary breast tumours, especially on a genomic level, and as such will be eradicated by the systemic therapy chosen. In this study we used high-resolution aCGH to investigate DNA copy number differences between primary breast cancers and their paired LNMs. To date, no recurrent LNM-specific genomic aberrations have been identified using array comparative genomic hybridization (aCGH) analysis. In our study we employ a high-resolution platform and we

SUBMITTER: Vollebergh MA 

PROVIDER: S-EPMC4118860 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature