Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase.

ABSTRACT:

Background

Thyroid hormones have a key role in both the developing and adult central nervous system and skeletal muscle. The thyroid gland produces mainly thyroxine (T4) but the intracellular concentrations of 3,5,3'-triiodothyronine (T3; the transcriptionally active hormone) in the central nervous system and skeletal muscle are modulated by the activity of type 2 deiodinase (D2). To date no neurological syndrome has been associated with mutations in the DIO2 gene and previous studies in young and juvenile D2-knockout mice (D2KO) did not find gross neurological alterations, possibly due to compensatory mechanisms.

Aim

This study aims to analyze the motor phenotype of 3-and-6-month-old D2KO mice to evaluate the role of D2 on the motor system at adult stages in which compensat

SUBMITTER: Barez-Lopez S 

PROVIDER: S-EPMC4118963 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature