Reduced white matter integrity in sibling pairs discordant for bipolar disorder.

ABSTRACT:

Objective

Several lines of evidence indicate that white matter integrity is compromised in bipolar disorder, but the nature, extent, and biological causes remain elusive. To determine the extent to which white matter deficits in bipolar disorder are familial, the authors investigated white matter integrity in a large sample of bipolar patients, unaffected siblings, and healthy comparison subjects.

Method

The authors collected diffusion imaging data for 64 adult bipolar patients, 60 unaffected siblings (including 54 discordant sibling pairs), and 46 demographically matched comparison subjects. Fractional anisotropy was compared between the groups using voxel-wise tract-based spatial statistics and by extracting mean fractional anisotropy from 10 regions of interest. Additiona

SUBMITTER: Sprooten E 

PROVIDER: S-EPMC4119087 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature