Risk of febrile seizures after first dose of measles-mumps-rubella-varicella vaccine: a population-based cohort study.

ABSTRACT:

Background

The combination measles-mumps-rubella-varicella (MMRV) vaccine currently used in Canada (Priorix-Tetra) may increase the risk of febrile seizures relative to the separate vaccines (MMR and varicella) previously administered. We determined the risk of febrile seizure after the first dose of MMRV, as well as any additional risk for children at high risk for seizures because of pre-existing medical conditions.

Methods

In this retrospective, population-based cohort study, we compared the risk of seizures after the first dose of MMRV with the risk after same-day administration of separate MMR and varicella vaccines (MMR+V) in children 12 to 23 months of age in the province of Alberta. We deterministically linked vaccination data to health service utilization data for s

SUBMITTER: MacDonald SE 

PROVIDER: S-EPMC4119141 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature