Validity of the diagnostic criteria for chronic cerebrospinal venous insufficiency and association with multiple sclerosis.

ABSTRACT:

Background

The chronic cerebrospinal venous insufficiency theory proposes that altered cerebral venous hemodynamics play a role in the pathophysiology of multiple sclerosis. We aimed to explore the validity of this hypothesis by assessing the diagnostic criteria for chronic cerebrospinal venous insufficiency in persons with and without multiple sclerosis.

Methods

We compared the proportion of venous outflow abnormalities between patients with multiple sclerosis and healthy controls using extracranial Doppler ultrasonography and gadolinium-enhanced magnetic resonance venography. Interpreting radiologists were blinded to the clinical status of participants.

Results

We enrolled 120 patients with multiple sclerosis and 60 healthy controls. High proportions of both patient

SUBMITTER: Costello F 

PROVIDER: S-EPMC4119167 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature