Granulocyte colony-stimulating factor therapy for stem cell mobilization following anterior wall myocardial infarction: the CAPITAL STEM MI randomized trial.

ABSTRACT:

Background

Small studies have yielded divergent results for administration of granulocyte colony-stimulating factor (G-CSF) after acute myocardial infarction. Adequately powered studies involving patients with at least moderate left ventricular dysfunction are lacking.

Methods

Patients with left ventricular ejection fraction less than 45% after anterior-wall myocardial infarction were treated with G-CSF (10 μg/kg daily for 4 days) or placebo. After initial randomization of 86 patients, 41 in the placebo group and 39 in the G-CSF group completed 6-month follow-up and underwent measurement of left ventricular ejection fraction by radionuclide angiography.

Results

Baseline and 6-week mean ejection fraction was similar for the G-CSF and placebo groups: 34.8% (95% confiden

SUBMITTER: Hibbert B 

PROVIDER: S-EPMC4119168 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature