MutaCYP: Classification of missense mutations in human cytochromes P450.

ABSTRACT:

Background

Cytochrome P450 monooxygenases (CYPs) represent a large and diverse family of enzymes involved in various biological processes in humans. Individual genome sequencing has revealed multiple mutations in human CYPs, and many missense mutations have been associated with variety of diseases. Since 3D structures are not resolved for most human CYPs, there is a need for a reliable sequence-based prediction that discriminates benign and disease causing mutations.

Methods

A new prediction method (MutaCYP) has been developed for scoring de novo missense mutations to have a deleterious effect. The method utilizes only five features, all of which are sequence-based: predicted relative solvent accessibility (RSA), variance of predicted RSA among the residues in close sequence

SUBMITTER: Fechter K 

PROVIDER: S-EPMC4119178 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature