IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure.

ABSTRACT: Humans are frequently exposed to various airborne allergens in the atmospheric environment. These allergens may trigger a complex network of immune responses in the airways, resulting in asthma and other chronic airway diseases. In this study, we investigated the immunological mechanisms involved in the pathological changes induced by chronic exposure to multiple airborne allergens. Naive mice were exposed intranasally to a combination of common airborne allergens, including the house dust mite, Alternaria, and Aspergillus, for up to 8 wk. These allergens acted synergistically and induced robust eosinophilic airway inflammation, specific IgE Ab production, type 2 cytokine response, and airway hyperresponsiveness in 4 wk, followed by airway remodeling in 8 wk. Increased lung infiltration of

SUBMITTER: Iijima K 

PROVIDER: S-EPMC4119518 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature