Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin.

ABSTRACT: The onset of autoantibodies in systemic autoimmunity can be the result of a breakdown in tolerance at multiple checkpoints. Genetic, hormonal, and immunological factors can combine with environmental influences to accelerate the onset of disease and aggravate disease outcome. Here, we describe a novel mechanism relating to the regulatory role of Neutrophil Gelatinase Associated Lipocalin (NGAL) in modulating the levels of autoantibodies in pristane induced lupus. Following a single injection of pristane intraperitoneally, NGAL expression was induced in both the serum and spleen. Furthermore, NGAL deficient mice were more susceptible to the induction of pristane stimulated autoimmunity, and displayed higher numbers of autoantibody secreting cells and increased expression of activation induc

SUBMITTER: Pawar RD 

PROVIDER: S-EPMC4119527 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature