Predicted 25(OH)D score and colorectal cancer risk according to vitamin D receptor expression.

ABSTRACT:

Background

Despite accumulating evidence for the preventive effect of vitamin D on colorectal carcinogenesis, its precise mechanisms remain unclear. We hypothesized that vitamin D was associated with a lower risk of colorectal cancer with high-level vitamin D receptor (VDR) expression, but not with risk of tumor with low-level VDR expression.

Methods

Among 140,418 participants followed from 1986 through 2008 in the Nurses' Health Study and the Health Professionals' Follow-up Study, we identified 1,059 incident colorectal cancer cases with tumor molecular data. The predicted 25-hydroxyvitamin D [25(OH)D] score was developed using the known determinants of plasma 25(OH)D. We estimated the HR for cancer subtypes using the duplication method Cox proportional hazards model.

Re

SUBMITTER: Jung S 

PROVIDER: S-EPMC4119536 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature