LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cells.

ABSTRACT:

Rationale

Smooth muscle cell (myocyte) large-conductance calcium (Ca)(2+)-activated potassium (BK) channels are functionally significant modulators of arterial contractility. Arterial myocytes express both pore-forming BKα and auxiliary β1 subunits, which increase channel Ca(2+) sensitivity. Recently, several leucine-rich repeat containing (LRRC) proteins have been identified as auxiliary γ subunits that elevate the voltage sensitivity of recombinant and prostate adenocarcinoma BK channels. LRRC expression and physiological functions in native cell types are unclear.

Objective

Investigate the expression and physiological functions of leucine-rich repeat containing protein 26 (LRRC26) in arterial myocytes.

Methods and results

Reverse transcription polymerase chain reac

SUBMITTER: Evanson KW 

PROVIDER: S-EPMC4119551 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature