Sleep and circadian rhythm regulation in early Parkinson disease.

ABSTRACT:

Importance

Sleep disturbances are recognized as a common nonmotor complaint in Parkinson disease but their etiology is poorly understood.

Objective

To define the sleep and circadian phenotype of patients with early-stage Parkinson disease.

Design, setting, and participants

Initial assessment of sleep characteristics in a large population-representative incident Parkinson disease cohort (N=239) at the University of Cambridge, England, followed by further comprehensive case-control sleep assessments in a subgroup of these patients (n=30) and matched controls (n=15).

Main outcomes and measures

Sleep diagnoses and sleep architecture based on polysomnography studies, actigraphy assessment, and 24-hour analyses of serum cortisol, melatonin, and peripheral clock gene

SUBMITTER: Breen DP 

PROVIDER: S-EPMC4119609 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature