68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers.

ABSTRACT: We have developed a (68)Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.

SUBMITTER: Nichols B 

PROVIDER: S-EPMC4119763 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature