Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity.

ABSTRACT: Many studies have identified metabolic pathways that underlie cellular transformation, but the metabolic drivers of cancer progression remain less well understood. The Hippo transducer pathway has been shown to confer malignant traits on breast cancer cells. In this study, we used metabolic mapping platforms to identify biochemical drivers of cellular transformation and malignant progression driven through RAS and the Hippo pathway in breast cancer and identified platelet-activating factor acetylhydrolase 1B3 (PAFAH1B3) as a key metabolic driver of breast cancer pathogenicity that is upregulated in primary human breast tumors and correlated with poor prognosis. Metabolomic profiling suggests that PAFAH1B3 inactivation attenuates cancer pathogenicity through enhancing tumor-suppressing sign

SUBMITTER: Mulvihill MM 

PROVIDER: S-EPMC4119799 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature