Elevated circulating miR-150 and miR-342-3p in patients with irritable bowel syndrome.

ABSTRACT:

Background and aims

MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression and are thus of interest as diagnostic markers, and as clues to etiology and targets of intervention. This pilot study examined whether circulating miRNAs are differentially expressed in patients with IBS.

Methods

miRNA microarrays (NanoString) were run on the whole blood of 43 participants.

Results

hsa-miR-150 and hsa-miR-342-3p were found to be significantly elevated (FDR adjusted p≤0.05, ≥1.6 fold change) in IBS patients compared to healthy controls. Neither of these miRNAs showed any relationship to race or sex. hsa-miR-150 is associated with inflammatory bowel disorders and pain, and interacts with a protein kinase (AKT2) through which it may affect inflammatory pathw

SUBMITTER: Fourie NH 

PROVIDER: S-EPMC4119883 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature