Cell death and deubiquitinases: perspectives in cancer.

ABSTRACT: The process of cell death has important physiological implications. At the organism level it is mostly involved in maintenance of tissue homeostasis. At the cellular level, the strategies of cell death may be categorized as either suicide or sabotage. The mere fact that many of these processes are programmed and that these are often deregulated in pathological conditions is seed to thought. The various players that are involved in these pathways are highly regulated. One of the modes of regulation is via post-translational modifications such as ubiquitination and deubiquitination. In this review, we have first dealt with the different modes and pathways involved in cell death and then we have focused on the regulation of several proteins in these signaling cascades by the different deubiqu

SUBMITTER: Bhattacharya S 

PROVIDER: S-EPMC4119901 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature