Characterisation of familial colorectal cancer Type X, Lynch syndrome, and non-familial colorectal cancer.

ABSTRACT:

Background

Familial Colorectal Cancer Type X (FCCTX) is defined as individuals with colorectal cancer (CRC) who families meet Amsterdam Criteria-1 (AC1), but whose tumours are DNA-mismatch-repair-proficient, unlike Lynch syndrome (LS). FCCTX does not have an increased risk of extra-colonic cancers. This analysis compares epidemiologic and clinicopathologic features among FCCTX, LS, and 'non-familial' (non-AC1) CRC cases.

Methods

From the Colon Cancer Family Registry, FCCTX (n=173), LS (n=303), and non-AC1 (n=9603) CRC cases were identified. Questionnaire-based epidemiologic information and CRC pathologic features were compared across case groups using polytomous logistic regression.

Results

Compared with LS, FCCTX cases were less likely to be current (vs never) smoker

SUBMITTER: Shiovitz S 

PROVIDER: S-EPMC4119982 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature