Annexin A11 (ANXA11) gene polymorphisms are associated with sarcoidosis in a Han Chinese population: a case-control study.

ABSTRACT:

Objectives

To further identify the single-nucleotide polymorphisms (SNPs) that contribute to the genetic susceptibility to sarcoidosis, we examined the potential association between sarcoidosis and 15 SNPs of the ANXA11 gene.

Design

A case-control study.

Setting

A tuberculosis unit in a hospital of the university in China.

Participants

Participants included 412 patients with sarcoidosis and 418 healthy controls.

Methods

The selected SNPs were genotyped using the MALDI-TOF in the MassARRAY system.

Results

Statistically significant differences were found in the allelic or genotypic frequencies of the rs2789679, rs1049550 and rs2819941 in the ANXA11 gene between patients with sarcoidosis and controls. The rs2789679 A allele (p=0.00004, OR=1.42, 95% C

SUBMITTER: Feng X 

PROVIDER: S-EPMC4120255 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature