Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis.

ABSTRACT:

Objective

To determine whether valproate (VPA) monotherapy influences homocysteine metabolism in patients with epilepsy.

Design

Systematic review and meta-analysis.

Data sources

We searched all articles in English through PubMed, Web of Science and EMBASE published up to August 2013 concerning the homocysteine levels in VPA monotherapeutic patients with epilepsy.

Participants

VPA-treated patients with epilepsy (n=266) and matched healthy controls (n=489).

Outcome measures

Heterogeneity between studies was assessed using I(2) statistics. Pooled standardised mean difference (SMD) and 95% CIs were calculated using a random effect model.

Results

A total of eight eligible studies were enrolled in our meta-analysis. We compared the plasma levels of homo

SUBMITTER: Ni G 

PROVIDER: S-EPMC4120332 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature