Autologous haematopoietic stem cell transplantation following high-dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas: a Cochrane systematic review*.

ABSTRACT:

Objectives

We conducted a systematic review to compare the efficacy and adverse events of autologous haematopoietic stem cell transplantation (HSCT) following high-dose chemotherapy (HDCT) versus standard-dose chemotherapy (SDCT) in patients with locally advanced or metastatic non-rhabdomyosarcoma soft tissue sarcomas (NRSTS).

Setting

Patients were observed in hospital units specialised for cancer therapy.

Participants

The review evaluated 294 patients with 19 different subtypes of malignant NRSTS. The patients had a median age between 10 and 46 years (range 2-65) and were mostly men.

Primary and secondary outcome measure

The planned and measured primary outcomes were overall survival and treatment-related mortality. The planned and measured secondary outcomes

SUBMITTER: Peinemann F 

PROVIDER: S-EPMC4120440 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature