Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain.

ABSTRACT:

Background

Excess fibrin in blood vessels is cleared by plasmin, the key proteolytic enzyme in fibrinolysis. Neurological disorders and head trauma can result in the disruption of the neurovasculature and the entry of fibrin and other blood components into the brain, which may contribute to further neurological dysfunction.

Objectives

While chronic fibrin deposition is often implicated in neurological disorders, the pathological contributions attributable specifically to fibrin have been difficult to ascertain. An animal model that spontaneously acquires fibrin deposits could allow researchers to better understand the impact of fibrin in neurological disorders.

Methods

Brains of plasminogen (plg)- and tissue plasminogen activator (tPA)-deficient mice were examined and

SUBMITTER: Hultman K 

PROVIDER: S-EPMC4120644 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature