Project description:17α-hydroxyprogesterone caproate (17-OHPC) is included in a veterinary depot formulation approved in Japan for the prevention of implantation failure and abortion in cattle, but its molecular effects on the bovine endometrium remain unclear. In this exploratory RNA-seq study, six Holstein cattle were assigned to a 17-OHPC-containing formulation group (100 mg 17-OHPC plus 10 mg progesterone [P4]; n = 3) or a P4-alone group (100 mg P4; n = 3). Endometrial samples were collected during an untreated synchronized cycle on days 4 and 7, and during a second synchronized cycle on day 7 after treatment on day 4. RNA-seq was used to characterize treatment-associated endometrial transcriptomic profiles and gene-set enrichment patterns between the 17-OHPC/P4 formulation and P4-alone arms.

2026-06-16 | GSE334702 | GEO

17α-Hydroxyprogesterone Caproate and the Risk of Glucose Intolerance in Pregnancy: A Systematic Review and Meta-analysis.

Project description: Not available

| S-EPMC9218919 | biostudies-literature

The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth.

Project description: Not available

| S-EPMC5896763 | biostudies-literature

Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation.

Project description: Not available

| S-EPMC3165062 | biostudies-literature