Variants associated with susceptibility to pancreatic cancer and melanoma do not reciprocally affect risk.

ABSTRACT:

Background

Melanoma cases may exist in pancreatic cancer kindreds, whereas there is increased risk of pancreatic cancer in familial melanoma. The two cancers may share genetic susceptibility variants in common.

Methods

Three dbGaP (datasets in Genotypes and Phenotypes)-deposited GWAS (genome-wide association study) datasets (MD Anderson melanoma, PanScan 1, and PanScan 2 for pancreatic cancer) were used. Thirty-seven melanoma susceptibility variants in 22 genomic regions from published GWAS, plus melanoma-related genes and pathways were examined for pancreatic cancer risk in the PanScan datasets. Conversely, nine known pancreatic cancer susceptibility variants were examined for melanoma risk in the MD Anderson dataset.

Results

In the PanScan data, initial associations

SUBMITTER: Wu L 

PROVIDER: S-EPMC4120837 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature