Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer.

ABSTRACT: Bone marrow-derived endothelial progenitor cells (EPCs) infiltrate into sites of neovascularization in adult tissues and mature into functional blood endothelial cells (BECs) during a process called vasculogenesis. Human marrow-derived EPCs have recently been reported to display a mixed myeloid and lymphatic endothelial cell (LEC) phenotype during inflammation-induced angiogenesis; however, their role in cancer remains poorly understood. We report the in vitro differentiation of human cord blood CD133⁺CD34⁺ progenitors into podoplanin⁺ cells expressing both myeloid markers (CD11b, CD14) and the canonical LEC markers vascular endothelium growth factor receptor 3 (VEGFR-3), lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), and prospero homeobox 1 (

SUBMITTER: Van't Hull EF 

PROVIDER: S-EPMC4121340 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature