Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons.

ABSTRACT: A complex interplay between multiple chromatin modifiers is critical for cells to regulate chromatin structure and accessibility during essential DNA-templated processes such as transcription. However, the coordinated activities of these chromatin modifiers in the regulation of gene expression are not fully understood. We previously determined that the budding yeast histone H4 methyltransferase Set5 functions together with Set1, the H3K4 methyltransferase, in specific cellular contexts. Here, we sought to understand the relationship between these evolutionarily conserved enzymes in the regulation of gene expression. We generated a comprehensive genetic interaction map of the functionally uncharacterized Set5 methyltransferase and expanded the existing genetic interactome of the global chro

SUBMITTER: Martin GM 

PROVIDER: S-EPMC4121362 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature