Pattern of microRNA expression associated with different stages of alcoholic liver disease in rat models.

ABSTRACT: Emerging evidence has suggested that aberrant expression of micro (mi)RNAs contributes to the development of alcoholic liver injury (ALD). However, miRNA profiles distinguishing different stages of ALD have not yet been reported. The present study was designed to investigate the unique miRNA expression patterns at different stages of ALD in a rat model and analyze the gene functions and pathways of dysregulated miRNA‑targeted genes. Using microarray and stem‑loop quantitative polymerase chain reaction analyses, 16 miRNAs were identified as upregulated and 13 were identified as downregulated in an alcoholic steatohepatitis (ASH) group compared with the control group, while five miRNAs were identified to be upregulated and eight were identified to be downregulated in the alcoholic fatty live

SUBMITTER: Chen YP 

PROVIDER: S-EPMC4121398 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature