Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes.

ABSTRACT: Major depressive disorder (MDD) is a widespread, severe, debilitating disorder that markedly diminishes quality of life. Medication is commonly effective, but 20-30 % of patients are refractory to medical therapy. The surgical treatment of psychiatric disorders has a negative stigma associated with it owing to historical abuses. Various ablative surgeries for MDD have been attempted with marginal success, but these studies lacked standardized outcome measures. The recent development of neuromodulation therapy, especially deep brain stimulation (DBS), has enabled controlled studies with sham stimulation and presents a potential therapeutic option that is both reversible and adjustable. We performed a systematic review of the literature pertaining to DBS for treatment-resistant depression to

SUBMITTER: Morishita T 

PROVIDER: S-EPMC4121451 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature