Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial.

ABSTRACT:

Purpose

To investigate the efficacy and safety of aerobic training (AT) in patients with cancer with medically stable heart failure (HF).

Patients and methods

A retrospective analysis of 90 patients with cancer who have HF and who were randomly assigned to AT (n = 47) or guideline-based usual care (UC; n = 43) was performed. AT consisted of three supervised sessions per week at 20 to 45 minutes per session at 60% to 70% of heart rate reserve for 12 weeks followed by home-based sessions for 4 to 12 months. The primary end point was all-cause mortality and hospitalization. Secondary end points were other clinical events, safety, and change in exercise capacity (VO(2peak)) and health-related quality of life (HRQOL).

Results

Median follow-up was 35 months. In intention-to

SUBMITTER: Jones LW 

PROVIDER: S-EPMC4121507 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature