Genetic variation modifies risk for neurodegeneration based on biomarker status.

ABSTRACT:

Background

While a great deal of work has gone into understanding the relationship between Cerebrospinal fluid (CSF) biomarkers, brain atrophy, and disease progression, less work has attempted to investigate how genetic variation modifies these relationships. The goal of this study was two-fold. First, we sought to identify high-risk vs. low-risk individuals based on their CSF tau and Aβ load and characterize these individuals with regard to brain atrophy in an AD-relevant region of interest. Next, we sought to identify genetic variants that modified the relationship between biomarker classification and neurodegeneration.

Methods

Participants were categorized based on established cut-points for biomarker positivity. Mixed model regression was used to quantify longitudinal ch

SUBMITTER: Hohman TJ 

PROVIDER: S-EPMC4121544 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature