Tuberculosis Immune Reconstitution Inflammatory Syndrome in children initiating Antiretroviral Therapy for HIV infection: A systematic literature review.

ABSTRACT:

Background

People with HIV initiating combination antiretroviral therapy are at risk for tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). While this syndrome has been well researched in adults, little is known about the incidence, case fatality, underlying immunopathology and treatment approaches in children.

Methods

Major databases were searched for articles related to TB-IRIS in children. Data were abstracted using standardized forms.

Results

Thirteen studies were identified: 6 retrospective and 2 prospective cohort studies, 1 cross-sectional study, 3 case reports and 1 case series. In total, 303 cases of TB-IRIS were described, of which 270 were unmasking TB-IRIS, 12 paradoxical TB-IRIS and 21 were not classifiable due to lack of key i

SUBMITTER: Link-Gelles R 

PROVIDER: S-EPMC4121969 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature