Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration.

ABSTRACT: Polarized cell migration is essential for normal organism development and is also a critical component of cancer cell invasion and disease progression. Directional cell motility requires the coordination of dynamic cell-extracellular matrix interactions as well as repositioning of the Golgi apparatus, both of which can be controlled by the microtubule (MT) cytoskeleton. In this paper, we have identified a new and conserved role for the focal adhesion scaffold protein paxillin in regulating the posttranslational modification of the MT cytoskeleton through an inhibitory interaction with the α-tubulin deacetylase HDAC6. We also determined that through HDAC6-dependent regulation of the MT cytoskeleton, paxillin regulates both Golgi organelle integrity and polarized cell invasion and migration

SUBMITTER: Deakin NO 

PROVIDER: S-EPMC4121979 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature